Biomedical research grant awardee 2022

Transforming Rabies Treatment: High-Affinity Human Monoclonal Antibody Cocktail for Effective Post-Exposure Prophylaxis

Dr. Akanksha Chaturvedi

Scientist – D National Centre for Cell Science, Pune

Rabies is a deadly disease that claims the lives of thousands of people each year. The disease is primarily transmitted through the bites of rabid dogs, and changes in agricultural practices, deforestation, and urbanization have altered the animal-human interface, resulting in the emergence of new strains of the virus. This has led to an increased number of non-canine cases and a growing global health burden.

To tackle this problem, our research team is working on generating fully human monoclonal antibodies against Rabies. We aim to use memory B cells from vaccinated patients following a dog bite to generate high-affinity human monoclonal antibodies. Our goal is to create a library of these hmAbs that can handle future adaptation strategies by the virus or the emergence of new strains, providing an effective, affordable, and scalable treatment option for people who have been exposed to the virus.

By developing fully human monoclonal antibodies against Rabies, we hope to reduce the incidence of this deadly disease worldwide and save countless lives. Our research represents a significant step forward in the fight against Rabies, and we are committed to continuing our work until Rabies is no longer a threat to public health. Together, we can create a safer, healthier world for all.


Dr. Debasis Nayak

Indian Institute of Science Education and Research, Bhopal

Dr. Saurabh Bobdey

Armed Forces Medical College, Pune

Dr. Saurav Sen

Maharashtra University of Health Sciences, Nashik

India is rapidly transforming into a dynamic hub of intellectual innovation and discovery. To support the science and technology ecosystem in the country, the Sree Padmavathi Venkateswara Foundation has created peer- reviewed funding programs that recognize exceptional researchers with the potential to achieve ground-breaking results in areas of critical national
importance. Our foundation provides these researchers with generous funding and empowering mentorship to generate knowledge and develop sustainable solutions of the highest quality, particularly in the fields of biomedical and agricultural research. We also work on projects to deploy advanced knowledge and improve the income of small and marginal farmers. We believe that by working together, we can create sustainable solutions that will benefit not only India but also the world.

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